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Half-lives (hr) and degradation rate constant (kobs)of SQV prodrugs in intestinal and liver homogenate (1 mg/mL). Studies were conducted at 37 °C. Values reported are mean ± SD (n=3).
| Val-Val-SQV | Gly-Val-SQV | |||
|---|---|---|---|---|
| kobs (hr−1) × 102 | t1/2 (hr) | kobs (hr−1) × 102 | t1/2 (hr) | |
| Intestine | 2.3 ± 0.3 | 29.3 ± 4.2 | 2.8 ±0.3 | 24.2 ± 1.1 |
| Liver | 26.2 ± 2.7 | 2.7 ± 0.3 | 31.2 ± 2.6 | 2.2 ± 0.2 |
