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. Author manuscript; available in PMC: 2011 Sep 6.
Published in final edited form as: J Med Chem. 2008 Sep 13;51(19):6044–6054. doi: 10.1021/jm800533c

Scheme 4.

Scheme 4

Synthesis of C(4′), C(5)-unsubstituted analog 22.a

a Reagents: (a) pivaloyl chloride, DCM, TEA, room temperature; (b) i. LDA, THF, then acetaldehyde; ii. MnO2, CHCl3; (c) pyridinium tribromide, 33% w.t. HBr in HOAc; room temperature; (d) 4, EtOH, reflux.