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. Author manuscript; available in PMC: 2011 Sep 6.
Published in final edited form as: J Med Chem. 2008 Sep 13;51(19):6044–6054. doi: 10.1021/jm800533c

Scheme 6.

Scheme 6

Synthesis of cycloheptathiazolothiazole analog 29.a

a Reagents: (a) Br2, CCl4/H2O, room temperature; (b) thiourea, EtOH, room temperature; (c) Br2 in HOAc, room temperature; (d) 4, EtOH, reflux; (e) pivaloyl chloride, DCM, TEA, room temperature.