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IFN-γ activation of STAT3 induces DKK1 expression and inhibits β-catenin. U87MG cells and PFA were treated or not with IFN-γ in the presence of S3I for 48 h. Subsequently, active β-catenin level was measured by flow cytometry (A), and DKK1 level was measured by ELISA (B). Data represent a minimum of three independent experiments. *p < 0.05, compared with IFN-γ–treated cultures alone.
