Table 1. Anti-proliferative Activities of Sugar-Derived Novobiocin Analogues.

compound	n	R2	R1	SKBr3 (μM)	MCF7 (μM)
16a	2	OH	OH	10.68 ± 0.05a	10.04 ± 0.03
16b	2	OH	OH	6.96 ± 0.06	13.30 ± 0.21
17a	2	H	OH	7.87 ± 0.04	6.45 ± 0.13
17b	2	H	OH	29.98 ± 2.07	10.24 ± 0.21
18a	2	OH	H	5.07 ± 0.26	1.34 ± 0.18
18b	2	OH	H	3.11 ± 0.03	1.56 ± 0.20
19	1	OH	OH	14.37 ± 0.52	14.31 ± 0.40
20a	1	OH	H	22.16 ± 0.94	>100
20b	1	OH	H	21.46 ± 2.28	22.50 ± 0.40
DHN2				10.86 ± 0.47	11.29 ± 0.41

^aValues represent mean ± standard deviation for at least two separate experiments performed in triplicate.