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. 2011 Apr 26;589(Pt 14):3433–3440. doi: 10.1113/jphysiol.2011.205823

Figure 4. SK2 channels modulate NMDA receptor-mediated calcium signalling and synaptic plasticity.

Figure 4

SK2 channels are activated by calcium influx through voltage-gated calcium channels (VDCCs; P/Q-type channels in cerebellar Purkinje cells). SK conductances reduce calcium influx through NMDA receptor-associated channels, thus influencing the LTD/LTP balance. SK channel blockade thus promotes the induction of LTP in hippocampal pyramidal cells. It is conceivable that in cerebellar Purkinje cells SK channel blockade/amplification of NMDA receptor-mediated calcium transients would facilitate the induction of LTD instead. Calcium sources (VDCCs/NMDA receptors) are shown in red.