Table 1.
Frequency of the occurrence of various tumor types in Nf2 +/− mice
| Genetic background/gender
|
Osteosarcoma
|
Lymphomaa
|
Lung adenocarcinoma
|
Hepatocellular carcinoma
|
Fibrosarcomab
|
Hepatocellular adenoma
|
|---|---|---|---|---|---|---|
| Wild-type F1 | ||||||
| male (n = 11) | 0% | 0% | 46% (5) | 0% | 18% (2) | 18% (2) |
| female (n = 12) | 0% | 58% (7) | 42% (5) | 8% (1) | 0% | 8% (1) |
| Total (n = 23) | 0% | 30% (7) | 44% (10) | 4% (1) | 9% (2) | 13% (3) |
| Nf2 +/− f1 | ||||||
| male (n = 68) | 56% (38) | 12% (8) | 13% (9) | 13% (9) | 10% (7) | 4% (3) |
| female (n = 31) | 77% (24) | 23% (7) | 0% | 0% | 7% (2) | 0% |
| Total (n = 99) | 63% (62) | 15% (15) | 9% (9) | 9% (9) | 9% (9) | 3% (3) |
| Nf2 +/− F2 | ||||||
| male (n = 15) | 60% (9) | 0% | 13% (2) | 33% (5) | 13% (2) | 13% (2) |
| female (n = 30) | 47% (14) | 17% (5) | 3% (1) | 3% (1) | 0% | 7% (2) |
| Total (n = 45) | 51% (23) | 11% (5) | 7% (3) | 13% (6) | 4% (2) | 9% (4) |
| Nf2 +/− 129Sv | ||||||
| male (n = 18) | 67% (12) | 0% | 11% (2) | 28% (5) | 6% (1) | 11% (2) |
| female (n = 19) | 84% (16) | 11% (2) | 0% | 0% | 0% | 5% (1) |
| Total (n = 37) | 76% (28) | 5% (2) | 5% (2) | 14% (5) | 3% (1) | 8% (3) |
| Total NF2 +/Ün = 181) | 63% (114) | 12% (22) | 8% (14) | 11% (19) | 7% (12) | 6% (10) |
a
This category includes lymphoblastic, lymphocytic, and follicular center cell lymphoma.
b
These tumors exhibit a range of features consistent with both fibrosarcomas and rhabdomyosarcomas, often within the same primary tumor.