Figure 1. In vivo renal parameters in WT and KO mice infused with DMSO vehicle, chromanol or clofilium.

WT mice, hatched bars; KO mice, filled bars. Chromanol, 4 mg kg⁻¹ h⁻¹ maintenance dose; clofilium, 76 μg kg⁻¹ min⁻¹ maintenance dose. FE, fractional excretion (Na⁺, Cl⁻, K⁺, glucose, water); V, urine flow rate. *Significant difference from WT vehicle; †significant difference from KO vehicle. n = 8 for WT vehicle, n = 9 for KO vehicle, n = 6 for WT chromanol, n = 9 for KO chromanol, n = 10 for WT clofilium, n = 9 for KO clofilium.