Figure 2. In vivo HCO₃⁻ handling data in WT and KO mice infused with DMSO vehicle, chromanol or clofilium.

WT mice, hatched bars; KO mice, filled bars. Chromanol, 4 mg kg⁻¹ h⁻¹ maintenance dose; clofilium, 76 μg kg⁻¹ min⁻¹ maintenance dose. , plasma HCO₃⁻ concentration; , HCO₃⁻ clearance; , urinary excretion HCO₃⁻; , fractional excretion of HCO₃⁻. n = 14 for WT vehicle, n = 6 for WT ACTZ, n = 16 for KO vehicle, n = 6 for KO ACTZ, n = 6 for WT chromanol, n = 9 for KO chromanol, n = 10 for WT clofilium, n = 9 for KO clofilium. *Significant difference from WT vehicle; †significant difference from KO vehicle.