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. 2011 May 24;589(Pt 14):3641–3658. doi: 10.1113/jphysiol.2011.210047

Figure 2. Muscimol injection into the MnPO blocks shivering, non-shivering thermogenic and cardiac responses to skin cooling.

Figure 2

A, changes in Tskin, EMG, TBAT, HR, arterial pressure (AP), rectal temperature (Trec) and brain temperature (Tbrain) that are evoked by repeated skin cooling. Saline or muscimol was nanoinjected into the MnPO at the dashed lines. B, location of the sites of saline and muscimol injections. 3V, third ventricle; ac, anterior commissure; ox, optic chiasm. C, representative view of a site of an injection into the MnPO. The injection site is clearly identified as a cluster of fluorescent beads (arrow). D, group data showing skin cooling-evoked changes in physiological variables before injection, after saline injection or after muscimol injection into the MnPO (n = 6 per group). †P < 0.05; ††P < 0.01; †††P < 0.001, compared with the cooling before injection. *P < 0.05; **P < 0.01; ***P < 0.001, compared with the cooling after saline injection (Bonferroni post hoc test following a repeated measures one-way ANOVA).