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. 2011 Mar 2;2(1-2):69–75. doi: 10.18632/oncotarget.220

Table 1. Variations in the FAM190A coding region transcripts.

Deleted exons Consequence Predicted non-natural peptide sequence at the fusion joint*
4-5 Not in frame SSSSKMNSL~ESFPEINKGRX
6 Not in frame PEFPEPSK~QVQTX
7 In frame LKMKRVLQE~DIMKDECSM
7-8 In frame LKMKRVLQE~GKVRHLQKA‡
7-8-9 In frame LKMKRVLQE~GLNLKRLET
7-8-9-10 In frame LKMKRVLQE~ATYRNRIVS
7 and 9 In frame LKMKRVLQE~DIMKDECSMLKLQL
KEKDELISQLQEEL~GLNLKRLET§,∥
8 In frame LTEEPVPFK~GKVRHLQKA
8-9 In frame LTEEPVPFK~GLNLKRLET††
8-9-10 In frame LTEEPVPFK~ATYRNRIVS
9 In frame LISQLQEEL~GLNLKRLET§
9-10 In frame LISQLQEEL~ATYRNRIVS**
10 In frame TQTELLCYD~ATYRNRIVS

Before the ~ sign are listed the last nine aminoacidic residues of the exon preceding the deletion. After the ~ sign are listed the first nine aminoacidic residues of the exon following the deletion. An underline indicates the aminoacidic residues that would be created due to a frame-shift. These two not-in-frame deletions would create a truncated predicted polypeptide. X, stop codon. For HLA-A*0205, the cognate ligand structure - q - g-V- -L matches del7-8 and the structure -L- - -L- -L matches the joints produced by del7 and 9§ and del9§. For HLA-A3, the ligand structure -V- - - - I-K- matches del7 and 9, the structure -L- - -L- -Y- matches del9-10**, and the structure - -F- -L- -K- matches del8-9†† [26].