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. 2011 Sep 5;2011:372854. doi: 10.1155/2011/372854

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Copyright © 2011 Jian Liu et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Cardiac pathology and survival rate. (a) Cardiac hypertrophy was estimated by heart weight/body weight ratio. (b) Transcript expression levels of ANF in α-MyHC-Cre and CR-Pd/Pa-null hearts. (c) Assessment of cardiac ultrastructure by Transmission Electron Microscopy (TEM): representative images are shown of heart sections from α-MyHC-Cre, PPARα ^−/−, CR-PPARβ/δ ^−/−, and CR-Pd/Pa-null mice at the age of 35 weeks (image magnification: 12,000x). Arrows indicate lipid droplet. (d) Kaplan-Meier survival curves: survival rates of mice from α-MyHC-Cre, CR-PPARβ/δ ^−/−, CR-Pd/Pa-null, and control groups after 15 months were analyzed by the log-rank test (CR-PPARβ/δ ^−/− or CR-Pd/Pa versus α-MyHC-Cre, P < 0.001).