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. 2011 Sep 5;2011:372854. doi: 10.1155/2011/372854

Figure 4.

Figure 4

Expression of key determinants of mitochondrial biogenesis and mitochondrial proteins. (a) Real-time PCR measurement of transcript levels of NRF-1, NRF2 (a and b subunits), PGC-1α and -1β, and TFAM on samples from TMCM, PPARα −/−, TMPD, and TMPDPA hearts. (b) Western blotting analyses of relative protein levels of PGC-1α and TFAM on samples of nuclear proteins extracted from ventricular tissues of TMCM, PPARα −/−, TMPD, and TMPDPA mice. (c) Transcript expression of mitochondrial proteins on samples from TMCM, PPARα −/−, TMPD, and TMPDPA hearts. (d) Protein expression of mitochondrial proteins on samples from TMCM, PPARα −/−, TMPD, and TMPDPA hearts. (e) Transcript expression of mitochondrial fission and fusion proteins on samples from TMCM, PPARα −/|−, TMPD, and TMPDPA hearts. (f) Protein expression of mitochondrial fission and fusion proteins on samples from TMCM, PPARα −/−, TMPD, and TMPDPA hearts. (g) The mitochondrial DNA copy number on samples from TMCM, PPARα −/−, TMPD, and TMPDPA hearts. *P < 0.05 versus TMCM; **P < 0.01 versus TMCM.