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Rates of oxidative metabolism and cardiac function. (a) The rate of palmitate oxidation in isolated working hearts from TMCM, PPARα −/−, TMPD, and TMPDPA mice was measured using 2H2O-labeled palmitate. (b) The rate of glucose oxidation in isolated working hearts from TMCM, PPARα −/−, TMPD, and TMPDPA mice was measured using 14C-labeled glucose. *P < 0.05 versus TMCM; **P < 0.01 versus TMCM.
