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. Author manuscript; available in PMC: 2011 Sep 6.
Published in final edited form as: Cancer Lett. 2006 Oct 17;250(1):1–8. doi: 10.1016/j.canlet.2006.09.002

Figure 1. Bone marrow derived myeloid cells contribute to tumor angiogenesis.

Figure 1

Myeloid precursor cells adhere to angiogenic endothelium via activated α4β1 or β2 integrins. Stromal derived growth factor 1 (SDF-1), colony stimulating factors (GM-CSF and others) or β-defensin mobilize specific subsets of myeloid precursor cells. In the presence of specific cytokines and growth factors, these cells differentiate either into endothelial-like cells, which are directly incorporated into new blood vessels (green arrow), or into monocytes / macrophages, which support tumor growth in a indirect manner (blue arrow). While interleukin-10 promotes differentiation of monocytes into M2 macrophages, VEGF and other factors promote endothelial cell differentiation from progenitor cells.