Figure 2.

Acute administration of sertindole altered the distribution of firing rates in MAM-treated rats. A, Acute injection of sertindole (SAL+SER, dark gray bars) did not affect DA neuron firing rate distribution in untreated saline rats (SAL+VHC, white bars). B, In MAM rats, acute administration of 1.25 mg/kg sertindole (horizontal line bars) significantly altered the distribution of firing rates in MAM rats compared to the vehicle-treated MAM control (black bars) due to an increase in neurons firing at both low and high firing rates. In contrast, acute haloperidol did not alter firing rate distribution of DA neurons recorded in saline rats (C, SAL+HAL, light gray bars) or MAM rats (D, MAM+HAL, vertical line bars). White and black bars as in A and B. *Two-sample Kolmogorov–Smirnov test, p = 0.0161.