Table I.
The Composition of Different Microsponges Prepared by Oil in Oil Emulsion Solvent Diffusion Method
| Preparations (F) | Eudragit RS-100 (g) | Acetone (ml) | D/P ratioa | P/S ratiob | Span 80 | % w/v Mg stearate | Pore inducers | |
|---|---|---|---|---|---|---|---|---|
| Type | Weight (g) | |||||||
| F1 | 0.5 | 2.5 | 1:1 | 1:5 | − | 3 | − | − |
| F2 | 1 | 5 | 1:2 | 1:5 | − | 3 | − | − |
| F3 | 1.5 | 7.5 | 1:3 | 1:5 | − | 3 | − | − |
| F4 | 2 | 10 | 1:4 | 1:5 | − | 3 | − | − |
| F5 | 0.5 | 2.5 | 1:1 | 1:5 | − | 1.5 | − | − |
| F6 | 0.5 | 2.5 | 1:1 | 1:5 | − | 5 | − | − |
| F7 | 1 | 5 | 1:2 | 1:5 | − | 1.5 | − | − |
| F8 | 1 | 5 | 1:2 | 1:5 | − | 5 | − | − |
| F9 | 0.5 | 5 | 1:1 | 1:10 | − | 3 | − | − |
| F10 | 0.5 | 10 | 1:1 | 1:20 | − | 3 | − | − |
| F11 | 0.5 | 20 | 1:1 | 1:40 | − | 3 | − | − |
| F12 | 0.5 | 5 | 1:1 | 1:10 | + | 3 | − | − |
| F13 | 0.5 | 10 | 1:1 | 1:20 | + | 3 | − | − |
| F14 | 0.5 | 20 | 1:1 | 1:40 | + | 3 | − | − |
| F15 | 0.5 | 2.5 | 1:1 | 1:5 | + | 3 | − | − |
| F16 | 2 | 10 | 1:4 | 1:5 | − | 3 | Sucrose | 0.5 |
| F17 | 2 | 10 | 1:4 | 1:5 | − | 3 | Sucrose | 1.5 |
| F18 | 2 | 10 | 1:4 | 1:5 | − | 3 | PGS | 0.5 |
| F19 | 2 | 10 | 1:4 | 1:5 | − | 3 | PGS | 1.5 |
All microsponges were prepared by using 0.5 g of drug and 150 ml of liquid paraffin. Magnesium stearate was added as a percentage weight relative to the acetone volume
aDrug/polymer ratio
bPolymer/solvent ratio