Table 2.
Origin of tumors observed in IRF-1−/−p53−/− ↔ p53−/− chimeric mice
|
Case
|
Sex
|
Survival (days)
|
Tumor type
|
Genotype of tumora
|
|---|---|---|---|---|
| 1 | M | 71 | thymic lymphoma | IRF-1−/−p53−/− |
| 2 | M | 90 | thymic lymphoma | IRF-1−/−p53−/− |
| 3 | F | 95 | thymic lymphoma | p53−/− |
| angiosarcoma | p53−/− | |||
| 4 | M | 96 | angiosarcoma | IRF-1−/−p53−/− |
| 5 | M | 98 | lipoma | IRF-1−/−p53−/− |
| 6 | M | 110 | sarcoma (NOSb) | p53−/− |
| 7 | M | 113 | angiosarcoma | IRF-1−/−p53−/− |
| 8 | M | 131 | angiosarcoma | IRF-1−/−p53−/− |
| 9 | M | 153 | generalized lymphoma | IRF-1−/−p53−/− |
| 10 | M | 190 | thymic lymphoma | IRF-1−/−p53−/− |
| generalized lymphoma | IRF-1−/−p53−/− |
a
The genotype of each tumor was determined by PCR or Southern blot analysis of the IRF-1 and p53 alleles as described (Matsuyama et al. 1993; Tsukada et al. 1993).
b
Not otherwise specified.