Table V.
Dissolution Parameters for the Matrices Containing Various APIs and Polymers
| API | Polymer | AUC12 h (% h) | DE12 h (%) | MDT12 h (h) | MDR12 h (% h−1) | Release rate (% h−1/2) |
|---|---|---|---|---|---|---|
| Ibuprofen | PEO | 706.79 | 58.90 | 4.85 | 8.72 | 33.97 ± 3.10 |
| NaCMC | 629.79 | 52.48 | 5.27 | 7.48 | 32.96 ± 3.28 | |
| PEO/NaCMC | 739.04 | 61.59 | 4.30 | 8.66 | 33.54 ± 10.68 | |
| Theophylline | PEO | 785.77 | 65.48 | 4.08 | 10.43 | 34.91 ± 5.81 |
| NaCMC | 996.63 | 83.05 | 1.99 | 15.33 | 38.44 ± 3.60 | |
| PEO/NaCMC | 952.69 | 79.39 | 2.33 | 13.91 | 38.27 ± 2.95 | |
| Propranolol HCl | PEO | 717.52 | 59.79 | 4.26 | 10.72 | 30.44 ± 1.03 |
| NaCMC | 941.56 | 78.46 | 2.55 | 11.30 | 37.56 ± 6.54 | |
| PEO/NaCMC | 539.81 | 44.98 | 4.42 | 8.11 | 22.58 ± 2.73 |