Table V.

Advantages and Limitations of Single-Particle Light Scattering Analysis

Advantage	Importance	Disadvantage	Importance
Relatively rapid in comparison to CI	High	Lack of API specificity	High
High size resolution (>10 channels/decade)	Moderate	Particles assumed to be spherical	High for DPIs; otherwise low
Moderate dynamic range (2 orders of magnitude)	High	Count- rather than mass-weighted data	High
Low intrinsic measurement variability (CofV typically <5% for size metrics)	High	Invasive sampling of aerosol generally is required	High
		Calibration against droplets or spherical particles of known size needed	High
		Some designs have ambiguous region between 1 and 3 μm in region where Mie scattering oscillations in Isca are important- can be improved by use of white light with right-angle scattering	High