Table III.
Pharmacokinetic Parameters of Tetrandrine after Intravenous Administration of SLNs and Solution with Dose of 16 mg/kg in Rats (n = 6)
Formulation | AUC(0-∞) (μgh/L) | C max (μg/L) | t 1/2 (h) | MRT(0-∞) (h) | CL (L/h/kg) |
---|---|---|---|---|---|
TET–SLNs | 6,581.50 ± 1,539.41 | 1,103.43 ± 94.31 | 13.86 ± 3.27 | 19.37 ± 4.60 | 2.52 ± 0.50 |
TET solution | 3,081.94 ± 728.21 | 630.18 ± 183.45 | 7.22 ± 1.13 | 10.06 ± 1.57 | 5.41 ± 1.22 |