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. 2011 Aug 3;12(3):1011. doi: 10.1208/s12249-011-9665-3

Table III.

Pharmacokinetic Parameters of Tetrandrine after Intravenous Administration of SLNs and Solution with Dose of 16 mg/kg in Rats (n = 6)

Formulation AUC(0-∞) (μgh/L) C max (μg/L) t 1/2 (h) MRT(0-∞) (h) CL (L/h/kg)
TET–SLNs 6,581.50 ± 1,539.41 1,103.43 ± 94.31 13.86 ± 3.27 19.37 ± 4.60 2.52 ± 0.50
TET solution 3,081.94 ± 728.21 630.18 ± 183.45 7.22 ± 1.13 10.06 ± 1.57 5.41 ± 1.22