Table 2.

Group effects and group × age interactions

Seed	Connectivity	Group Difference				Group × Age Interaction
		Directiond	x, y, z	Z	ke	Directiond	x, y, z	z	ke
L	rACC	HC > ODC	6, 39, 6	3.82	68a	HC1 > OCD1	−6, 51, 12	3.47	45
DC						HC2,3,4 = OCD2, 3, 4
R	Medial frontal pole	OCD > HC	15, 69, 9	3.47	43b
DC
L	L dACC	------	------	------	------	HC1 > OCD1	−9, 27, 27	3.42	39c
MT						OCD2 > HC2
						OCD3,4 = HC3,4
R	Bilateral dACC	------	------	------	----	HC1 > OCD1	−6, 24, 33	3.76	194
MT						HC2, 3, 4 = OCD2, 3, 4	9, 15, 36	3.73

Note: dACC = dorsal anterior cingulate cortex, DC = dorsal caudate, HC = healthy control, L = left, R = right, MT = medial-dorsal thalamus, OCD = obsessive compulsive disorder, rACC = rostral anterior cingulate cortex,.

^aExclusion of medicated patients in post-hoc analysis revealed a trend towards group × age interaction (HC₁ > OCD_1; HC_2,3,4 = OCD_{2, 3, 4}), but no main effect of group.

^bTwenty-six of the 43 voxels in this cluster extended laterally from the medial frontal cortext (MFC) search volume.

^cExclusion of patients with subclinical obsessive compulsive disorder (OCD) symptoms revealed reduced connectivity in child patients, but no difference between adolescent patients and controls.

^dPlanned contrasts at each developmental stage (1 = Child, 2 = Adolescent, 3 = Young Adult, 4 = Older Adult; p < .05, corrected).

^eCluster-level significant at p < .05, corrected for multiple comparisons within medial frontal cortex search volumes.