TABLE 1.
Clinical Characteristics of Samples Used in this Study.
| Data set | Training set | Bild test set | Raponi test set | Validation set | |
|---|---|---|---|---|---|
| Platform | U133A | U133 plus2.0 | U133A | qRT-PCR | |
| Sample number | 439 | 111 | 130 | 101 | |
| Type of cancer | AD | 58 AD/53 SCC | SCC | AD | |
| Age average (SD) | 64.4 (10.1) | 64.8 (9.6) | 67.5 (9.9) | 67.0 (9.6) | |
| Gender | |||||
| Female | 218 (49.7%) | 48 (43.2%) | 48(36.9%) | 53(52.5%) | |
| Male | 221 | 63 | 82 | 48 | |
| Stage | |||||
| Stage I | 276(62.9%) | 67(63.2%) | 73(56.2%) | 59(58.4%) | |
| Stage II | 104 | 18 | 34 | 16 | |
| Stage III | 59 | 21 | 23 | 26 | |
| Differentiation | |||||
| Well | 60 | NA | 15 | 28 | |
| Moderate | 208 | NA | 76 | 38 | |
| Poor | 166(38.3%) | NA | 39(30%) | 34(33.7%) | |
| Dead (5 year) | 186(42.4%) | 58(52.3%) | 52(40%) | 44(43.6%) | |
| Alive | 253 | 53 | 78 | 57 | |
| Median survival (m) | 47 | 31.1 | 34.5 | 28.8 | |
| Adjuvant therapy | 108 | unknown | 48 | 42 | |
| No adjuvant therapy | 329 | unknown | 69 | 58 | |
Abbreviation: AD, adenocarcinoma; SCC, squamous cell cancer. Adjuvant therapy includes chemo- and/or radio-therapy.