Table 2.

Histological scores of bone defect-healing at eight weeks postoperatively

Score parameter	Control	Low dose	High dose
Fibroblast density	0.8 ± 0.6	1.3 ± 0.5	2.3 ± 0.6
Vascularity	1.1 ± 0.6	1.2 ± 0.4	2.4 ± 0.5
Haversian channels	0.0 ± 0.0	0.0 ± 0.0	1.4 ± 0.5
Osteoid synthesis	0.1 ± 0.3	0.2 ± 0.4	2.2 ± 0.7
Total	2.0 ± 1.1	2.7 ± 1.3 **	8.4 ± 2.0*

All values are given as the mean and standard deviation for each parameter

*p < 0.01 vs. the control; ** p > 0.05 vs. the control