Table 7a.
Association between formaldehyde and lymphatic leukemia (ICD 204)
| Beane Freeman et al., 2009 | Blair et al., 2001 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| NCI cohort (1934–2004) | US industrial workers | |||||||||
| Measures | Category | Obs | Estimate | 95% CI | Category | Obs | Estimate | 95% CI | ||
| Acute | ||||||||||
| Unexposed/Exposed | Unexposed | 1 | SMR | 0.26 | 0.04–1.82 | Low | 0 | OR | — | — |
| Exposed | 36 | SMR | 1.15 | 0.83.1.59 | High | 0 | OR | — | — | |
| Chronic | ||||||||||
| Low | 29 | OR | 1.20 | 0.70–1.80 | ||||||
| High | 1 | OR | 0.60 | 0.10–5.30 | ||||||
| Peak Exposure | 0 ppm | 1 | RR | 0.27 | 0.03–2.13 | |||||
| >0–<2.0 ppm | 14 | RR | 1.00 | — | ||||||
| 2.0–<4.0 ppm | 8 | RR | 0.81 | 0.33–1.96 | ||||||
| ≥4.0 ppm | 14 | RR | 1.15 | 0.54–2.47 | ||||||
| ptrend > 0.5 (exposed) | ||||||||||
| ptrend = 0.3 (exposed and unexposed) | ||||||||||
| Average Intensity | 0 ppm | 1 | RR | 0.26 | 0.03–2.01 | |||||
| >0–<0.5 ppm | 22 | RR | 1.00 | — | ||||||
| 0.5–<1.0 ppm | 7 | RR | 0.92 | 0.39–2.16 | ||||||
| ≥1.0 ppm | 6 | RR | 1.61 | 0.76–3.39 | ||||||
| ptrend > 0.5 (exposed) | ||||||||||
| ptrend > 0.5 (exposed and unexposed) | ||||||||||
| Cumulative Exposure | 0 ppm-yr | 1 | RR | 0.24 | 0.03–1.88 | |||||
| >0–<1.5 ppm-yr | 21 | RR | 1.00 | — | ||||||
| >1.5–<5.5 ppm-yr | 5 | RR | 0.57 | 0.21–1.54 | ||||||
| ≥5.5 ppm-yr | 10 | RR | 1.02 | 0.47–2.21 | ||||||
| ptrend = 0.46 (exposed) | ||||||||||
| ptrend = 0.41 (exposed and unexposed) | ||||||||||
| Cumulative number of peaks ≥4.0 ppm | No association. Results not shown. | |||||||||
| Duration of Employment | No association. Results not shown. | |||||||||