Table 16.
Peripheral blood changes |
|||||||
---|---|---|---|---|---|---|---|
Study | Exposure (ppm) | Number of persons (exposed, control) | % change in WBC count between groups or % of subjects with decreased hematology parameters | Total WBC | Platelets | Hb | Other findings |
Yang et al., 2007* | 0.018–0.036 | 239, 200 | WBCs: 14% (E) vs. 4% (C) Platelets: 11% (E) vs. 1% (C) RBCs: 32% (E) vs. 21.5% (C) | ↓↓ | ↓↓ | ↓↓ | |
Kuo et al., 1997 | ND–0.054 (personal samples) 0.006–0.237(area samples) | 50, 71 | NA | ↓ | NS | NS | Statistically significant (-0.33, p < .05) inverse relationship between FA and WBC counts, but not 11 other hematology parameters |
Cheng et al., 2004* | 0.2.0.76 | 72, 150 | WBCs: 14% in E vs. 5% in C | ↓ | NA | NA | |
Lyapina et al., 2004 | 0.52–1.049 (mean, 0.71) | 29, 21 | NA | NS | NS | NR | Statistically significant inverse relationship between duration of exposure to formaldehyde and RBC counts and Hct |
Xu et al., 2007* | 0.36–5.56 | 10, 10 | −11.4 | NS | NS | NS | |
Ye et al., 2005 | 0.8 (8-h TWA), 1.38 (max) in workers; vs. 0.009 (mean), 0.012 (max) in controls | 36, 6 | NA | NA | NA | NA | Workers vs. students in dorms. Statistically significantly increased B lymphocytes. Statistically significantly decreased CD3 and CD8 but not CD4 T lymphocytes in peripheral blood |
As above | 0.09 (5-h TWA), 0.24 (max); vs. 0.009 (mean), 0.012 (max) in controls | 18, 6 | NA | NA | NA | NA | Waiters vs. students in dorms. No change in B or T lymphocytes counts in peripheral blood |
Zhang et al., 2010b | 0.63–2.51 (mean, 1.28) | 43, 51 | −13.5 | ↓↓ | ↓ | NS | Decreased RBC; increased MCV (statistically significant) |
Qian et al., 1988* | 2.44 (estimated) | 55, 41 | −13.3 | ↓↓↓ | NA | NA | Increase in immunoglobulins (Ig) IgM and IgA, and eosinophils (no statistical significance reported) |
Feng et al., 1996* | 0.57–15.61 | 104, 68 | NA | NS | NA | NS | |
Srivastava et al., 1992 | NR | 6, 0 | Increased blood lymphocyte counts in 3 of 6 subjects | NA | NA | Decrease | Decreased Hb in 4 of 6 subjects |
Tang et al., 2003* | NR | 110, 120 | −17.1 | NS | NA | NA | Decreased WBC count with increasing work years (no statistical significance reported) |
Tong et al., 2007* | NR | 65, 70 | −18 | ↓↓↓ | ↓↓↓ | NS | WBC and platelet counts decreased with increasing work years (no statistical significance reported) |
Note. E = exposed group; C = control group; NR = not reported; NS = not statistically significant; NA = not applicable/available; WBC = white blood cell count in peripheral blood; RBC = red blood cell count in peripheral blood; Hct = hematocrit; Hb = hemoglobin content of RBCs;
statistically significant decrease (p < .05);
statistically significant decrease (p < .01);
statistically significant decrease (p < .001).
As cited in Tang et al. (2009). These studies are in Chinese and are not available on PubMed.