Table 2.
Increased dosage of sel-10 reduces lin-12 activity
A. Suppression of phenotypes associated with increased lin-12 activity | |
---|---|
Relevant genotype
|
% 0AC (n)
|
lin-12(d); dpy-20;Ex[sel-10(+) dpy-20(+)] | 51 (47) |
lin-12(d); dpy-20;Ex[dpy-20(+)] | 95 (44) |
B. Enhancement of phenotypes associated with reduced lin-12 activity | |
Relevant genotype | % 2AC (n) |
lin-12(h); dpy-20;Ex[sel-10(+) dpy-20(+)] | 97 (34) |
lin-12(h); dpy-20;Ex[dpy-20(+)] | 30 (40) |
lin-12(+); dpy-20(e1282);Ex[sel-10(+) dpy-20(+)] | 0 (87) |
Complete genotypes: lin-12(d) = lin-12(n379), lin-12(h) = lin-12(ar170), dpy-20dr(h) = dpy-20(e1282), Ex[sel-10(+) dpy-20(+)] = arEx93, Ex[dpy-20(+)] = arEx149. (See Materials and Methods for details of strain constructions). Non-Dpy animals segregating from the strains were scored in the L3 stage for the number of anchor cells.