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Chronic leptin treatment normalizes fasting plasma glucose independent of food intake and body weight. Shown are food intake (A), body weight (B), fasting plasma leptin (C), and fasting plasma glucose (D) in diabetic UCD-T2DM rats injected with saline or leptin (0.5 mg/kg SC) twice daily for 1 mo. ++P < 0.01 by two-way ANOVA; ***P < 0.001 compared with control by Bonferroni's posttest; and #P < 0.05 compared with baseline by Student's t test. Values are expressed as mean ± SEM.
