Skip to main content
. 2011 Jul 18;108(35):E607–E616. doi: 10.1073/pnas.1103546108

Fig. 1.

Fig. 1.

Firing patterns of CA1 pyramidal cells during SPW-Rs. (A) Original recordings from a cell that participates in SPW-Rs. Upper shows intracellular recording with two action potentials, and Lower shows field sharp wave ripple complexes. (B) Original recording from a cell (Upper) that does not fire during SPW-Rs (Lower). (C) Expanded trace from the cell in A showing an action potential during the field SPW-R (marked with an asterisk in A). (D) Expanded trace from the nonparticipating cell shown in B. The sharp wave is accompanied by a subthreshold synaptic potential. (E Left) Event cross-correlogram showing precision of firing during SPW-Rs (data from the cell shown in A and C). (Left Inset) Cumulative plot of spikes within one ripple cycle (red box around the central peak of the cross-correlogram). In this cell, 50% of action potentials occurred within 23% of a full ripple cycle, indicating strong phase-coupling to ripples. (Right) Loss of phase coupling on shuffling of spikes and ripples. Cross-correlogram was constructed between spikes and ripples from the subsequent SPW-R event. Cumulative plot (Right Inset) shows loss of coupling.