Table 1.
Rat strain/stocka |
Day 7 PI
|
Day 14 PI
|
Day 28 PI
|
Day 56 PI
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Number of rats shedding virusb |
Copies of virus shed in fecesc |
Min/Maxd |
Number of rats shedding virusb |
Copies of virus shed in fecesc |
Min/Maxd |
Number of rats shedding virusb |
Copies of virus shed in fecesc |
Min/Maxd |
Number of rats shedding virusb |
Copies of virus shed in fecesc |
Min/Maxd |
|
BN | 11/11 | 4.13 × 105 | 1.24 × 105 9.26 × 105 |
11/11 | 8.6 × 103 | 5.43 × 102 3.68 × 104 |
4/11 | 5.78 × 102 | 0 2.89 × 103 |
3/11 | 4.5 × 101 | 0 3.13 × 102 |
F344 | 11/11 | 4.91 × 105 | 1.37 × 105 1.10 × 106 |
11/11 | 7.39 × 104 | 6.64 × 103 5.06 × 105 |
5/11 | 5.89 × 102 | 0 4.46 × 103 |
1/11 | 6.6 × 101 | 0 7.13 × 102 |
HSD:rnu | 10/10 | 1.47 × 106 | 8.40 × 105 3.14 × 106 |
10/10 | 1.08 × 106 | 1.37 × 105 2.43 × 106 |
10/10 | 2.61 × 105 | 1.08 × 104 5.15 × 105 |
10/10 | 3.45 × 105 | 7.03 × 104 6.39 × 105 |
Tac:rnu | 10/10 | 9.0 × 105 | 5.70 × 105 1.42 × 106 |
10/10 | 2.26 × 105 | 3.63 × 104 7.85 × 105 |
10/10 | 1.33 × 105 | 4.87 × 104 2.31 × 105 |
10/10 | 1.13 × 105 | 2.42 × 104 2.58 × 105 |
BN-Brown Norway and F344-Fischer rats (immunocompetent strains, n=11/group) and Hsd:RH-Fox1rnu and NTac:NIH-Whn nude rats (immunocompromised stocks, n=10/group) were inoculated by oral gavage with 2.5 × 106 PFU RTV1. Sham inoculated rats (n=6 per group) were inoculated with uninfected BHK cell lysates by oral gavage.
Number of rats infected/number of rats inoculated with RTV.
Represents mean number of viral copies per mg of feces from rats actively shedding virus.
Values from rats shedding the lowest and highest number of viral copies within groups.