Figure 1.

Schematic organisation of genomic and subgenomic HEV RNAs. ORF1 encodes a nonstructural polyprotein; ORF2 encodes the capsid protein; ORF3 encodes a phosphoprotein. Met, methyltransferase; Y, no function assigned at present; Pr, putative papain-like cysteine protease; P, proline ‘hinge’; X, no function assigned at present; Hel, RNA helicase; RdRp, RNA-dependent RNA polymerase.^{51, 52}