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. 2011 May 19;39(16):7179–7193. doi: 10.1093/nar/gkr370

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© The Author(s) 2011. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 8. — Schematic representation of PROMPT/RNAPII gene, PROMPT/RNAPIII gene and RNAPII gene/RNAPIII gene relationships. (A) Gene and PROMPT transcription reside in the same gene compartment. This can lead to competition for available RNAPII and other transcription factors as conditions that reduce transcription of the protein-coding gene—here shown to be the result of a pA site mutation—allow the PROMPT to attract more RNAPII. (B) RNAPII activity upstream of RNAPIII genes can either take the form of PROMPT transcription (left) or expression of a neighboring, divergently transcribed protein-coding gene (right). See ‘Discussion’ section for more details.