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. 2011 May 17;39(16):6908–6918. doi: 10.1093/nar/gkr303

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© The Author(s) 2011. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Properties of MARs predicted upstream of miRNAs. (A) Number of MAR elements predicted upstream of miRNAs. MARs were observed in the upstream regions of vast majority (96%) of miRNA genes. (B) Distance of predicted MARS from miRNA genes. MARs were predicted at distances as short as 610 bp to 9.5 kb upstream of the miRNA genes. (C) DNA strand specificity of miRNAs and predicted MARs. miRNAs on both positive and negative strands have similar frequency of upstream MARs. (D) Intronic and intergenic miRNA genes have similar frequency of upstream MARs.