Table 2.
Heritability of total and free testosterone and SHBG in adult women from the FHS Generations 2 and 3: univariate analysis
| Total testosterone | SHBG | Free testosterone | |
|---|---|---|---|
| n | 2671 | 2677 | 2671 |
| h2 (se) | 0.263 (0.053) | 0.556 (0.052) | 0.259 (0.052) |
| P value | 1.00 × 10−7 | 7.29 × 10−30 | 3.25 × 10−8 |
| SHBG-adjusted analysisa | |||
| n | 2671 | 2671 | |
| h2 (se) | 0.246 (0.053) | 0.203 (0.052) | |
| P value | 3.00 × 10−7 | 1.24 × 10−5 |
Covariates included age, age2, BMI, BMI2, menopausal status, diabetes, and current smoking. h2, Heritability estimate.
a
Total and free testosterone heritability estimates adjusted for circulating SHBG in addition to age, age2, BMI, BMI2, menopausal status, diabetes, and current smoking.