Table II.
Clinical findings of antimelanoma differentiation-associated gene 5 patients
| Total (N = 77), N (%) |
anti-MDA5-positive (N = 10), N (%) |
anti-MDA5-negative (N = 67), N (%) |
P value | |
|---|---|---|---|---|
| Age onset, y ± SD | 48.2 ± 16 | 51.5 ± 8.8 | 47.7 ± 16.8 | .50 |
| Female | 51 (65) | 7 (87.5) | 44 (63.8) | .25 |
| Cancer | 12 (15.6) | 0 (0) | 12 (17.9) | .347 |
| Tobacco use | 19 (26) | 1 (10) | 18 (29) | .438 |
| Raynaud | 13 (25) | 3 (38) | 10 (22) | .389 |
| Interstitial lung disease | 16 (25) | 6 (67) | 10 (18) | .005 |
| Rapidly progressive lung disease | 5 (6.6) | 2 (22.2) | 3 (4.5) | .104 |
| Hand swelling | 9 (13.8) | 4 (40) | 5 (9.1) | .026 |
| Arthritis/arthralgia | 20 (31.2) | 7 (70) | 13 (24) | .0076 |
| Amyopathic | 10 (13) | 3 (30) | 7 (10) | .117 |
| Clinically amyopathic | 13 (16.9) | 5 (50) | 8 (11.9) | .010 |
| Skin ulceration (any) | 20 (26.0) | 8 (80) | 12 (18) | .0002 |
| Ulceration (Gottron) | 5 (6.5) | 3 (30) | 2 (3) | .0142 |
| Ulceration (digit pulp/periungual) | 11 (14.3) | 8 (80) | 3 (4.5) | <.0001 |
| Ulceration (elbow) | 4 (5.2) | 3 (30) | 1 (1.5) | .0061 |
| Ulceration (chest/arms) | 6 (7.8) | 0 (0) | 6 (9) | 1.000 |
| Palmar papules | 7 (9.6) | 6 (60) | 1 (1.6) | <.0001 |
| Mechanic hands | 15 (22.4) | 6 (67) | 9 (15.5) | .0028 |
| Panniculitis | 2 (3.1) | 2 (20) | 0 (0) | .0216 |
| Calcinosis cutis | 3 (4.8) | 1 (11.1) | 2 (3.7) | .375 |
| Alopecia | 22 (34) | 7 (78) | 15 (27) | .0053 |
| Heliotrope rash | 42 (60) | 7 (70) | 35 (58) | .729 |
| Gottron papules | 38 (53.5) | 7 (70) | 31 (51) | .32 |
| Violaceous erythema | ||||
| Scalp | 42 (62.7) | 6 (67) | 36 (62) | 1.00 |
| Face | 57 (80.3) | 10 (100) | 47 (77) | .193 |
| V area of the chest-neck | 54 (79.4) | 8 (89) | 46 (78) | .673 |
| Elbow/knee | 48 (69.6) | 10 (100) | 46 (78) | .0259 |
| Periungual telangiectasia | 50 (73.6) | 9 (90) | 41 (71) | .27 |
| Pruritus | 44 (68.8) | 6 (67) | 38 (69) | 1.00 |
| Oral pain/ulcers | 9 (13.9) | 5 (50) | 4 (7.3) | .0029 |
Statistically significant associations (P < 0.05) are shown in bold.
MDA5, Melanoma differentiation-associated gene 5.