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. Author manuscript; available in PMC: 2011 Sep 6.
Published in final edited form as: Nucl Med Biol. 2009 Apr;36(3):247–258. doi: 10.1016/j.nucmedbio.2008.12.005

Table 2.

Total distribution volume (Vd) in baseline and SAHA inhibition studies.

Brain region Baseline 1mg/kg 0.50mg/kg 0.25mg/kg
str 14.2 6.90 12.34 11.5
cb 13.4 5.53 9.67 9.71
thl 10.9 3.92 6.81 7.19 )
tmp 9.0 3.87 5.42 6.60
cing 6.76 3.30 4.28 5.15
par 5.4 2.88 3.74 4.14
glb 4.84 2.91 3.57 3.79

The model parameter used for comparison is the total distribution volume, Vd for uptake and conversion of FAHA in brain tissue was determined from graphical analysis. Parameters for modeling the metabolite (FAC) uptake were fixed for all four studies (K1= 0.018 mL/min/cc; k2= 0.04 min−1; k3= 0.008 min−1; k4= .003 min−1.) and were used to estimate the uptake of [18F]FAC from peripheral metabolism of [18F]FAHA. Results for baseline and blocking studies for one animal (similar trends in Vd were observed for the second baboon).