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. 2011 Sep 6;5(9):e1308. doi: 10.1371/journal.pntd.0001308

Figure 2. Clearance of parasites from the brain following mel/HPβCD or mel/RAMβCD chemotherapy.

Figure 2

The ability of the melarsoprol cyclodextrin inclusion complexes to clear the trypanosomes form the brain was studied. (A) Animals were infected (I) with T.b.brucei. On day 21 post-infection one group (n = 6) of mice were sacrificed (K) while the remainder were treated with mel/HPβCD or mel/RAMβCD (M) at 0.05 mmol/kg. Further groups (n = 6) were sacrificed 24 hours following each drug administration. Days post-infection are indicated below the treatment schedule. Trypanosome load within the brain was assessed using Taqman PCR (Figure S1); (B,C) Interval plots of trypanosome load following each drug administration showing the mean and standard error of the mean are presented for mel/HPβCD and mel/RAMβCD respectively. Analyses of the data using the GLM procedure identified significant differences between the means (Table S2 & S3). (D) Interaction plot demonstrates no significant interaction between mel/HPβCD and mel/RAMβCD treatment and the trypanosome load after each administration (P = 0.813).