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. 2011 Jul 28;12:307. doi: 10.1186/1471-2105-12-307

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Copyright ©2011 Fontes and Soneson; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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The effect of the choice of null distribution. (a) The projection score as a function of log₁₀(α), where α is the p-value threshold obtained by applying a two-sided t-test for comparing two artificial sample groups, when is defined by assuming all matrix elements are normally distributed. (b) The projection obtained by applying PCA to the most informative variable subset, containing 11 variables.

Inline graphic — The effect of the choice of null distribution. (a) The projection score as a function of log₁₀(α), where α is the p-value threshold obtained by applying a two-sided t-test for comparing two artificial sample groups, when is defined by assuming all matrix elements are normally distributed. (b) The projection obtained by applying PCA to the most informative variable subset, containing 11 variables.