Growth of different strains of S. maltophilia in the lungs of A/J mice. Animals were intranasally inoculated with strain UPSm1 (a, ▴) or UPSm4 (b, ○) resulting in comparable levels of deposition (t = 0), and then at 4, 8, 12 and 24 h post-inoculation, the c.f.u. in total lung homogenates were determined by plating. Data are the mean±sd obtained from five infected animals and are representative of at least two independent experiments. Significant increases in c.f.u. relative to the values at t = 0 were obtained only at 4 h in (a) and (b) (Student's t test, P<0.05).