Table 3.
Post primary series opsonophagocytic activity assay (OPA) geometric mean titers (GMT), measured 3-6 weeks after the third pneumococcal conjugate vaccine (PCV) dose, in children who carried S. pneumoniae serotypes 6B, 19F or 23F prior to the first dose; or only detected at the 2nd and/or 3rd vaccine dose.
| Colonization status by serotype prior to first PCV dose |
Colonization status by serotype only prior to 2nd and/or 3rd PCV dose |
|||||
|---|---|---|---|---|---|---|
| Serotype 6B carriers vs . non- carriers |
6B-positive pre- vaccination(n=10) |
6B-negative pre- vaccination (n)* |
P-value | 6B-positive pre- vaccination (n=13) |
6B-negative pre- vaccination |
P-value |
| Anti-9V OPA GMT (Min, Max) | 805 (452, 1435) | 574 (513; 641) | 0.174 | 637 (369, 1099) | 572 (511, 641) | 0.592 |
| Anti-19F OPA GMT (Min, Max) | 423 (183; 976) | 278 (250, 311) | 0.184 | 394 (205, 756) | 276 (247, 309) | 0.261 |
| Anti-23F OPA GMT (Min, Max) | 2584 (867; 7707) | 1519 (1303;1770) | 0.124 | 1524 (606, 3835) | 1519(1300, 1775) | 0.959 |
| Serotype 19F carriers vs . non- carriers |
19F-positive pre- vaccination(n=9) |
19F-negative pre- vaccination |
P-value | 19F-positive pre- vaccination (n=17) |
19F-negative pre- vaccination |
P-value |
|---|---|---|---|---|---|---|
| Anti-9V OPA GMT (Min,Max) | 889 (590 1341) | 573 (513; 640) | 0.430 | 592 (342, 1024) | 573 (511, 641) | 0.965 |
| Anti-19F OPA GMT (Min, Max) | 17 (4, 80) | 296 (267, 328) | <0.0001 | 105 (41, 268) | 308 (279, 340) | <0.0001 |
| Anti-23F OPA GMT (Min, Max) | 4050 (1495,10972) | 1508 (1294, 1757) | 0.100 | 2460 (1391, 4350) | 1481 (1265, 1733) | 0.304 |
| Serotype 23F carriers vs . non- carriers |
23F-positive pre- vaccination (n=11) |
23F-negative pre- vaccination |
P-value | 23F-positive pre- vaccination (n=13) |
23F-negative pre- vaccination |
P-value |
|---|---|---|---|---|---|---|
| Anti-9V OPA GMT (Min, Max) | 964 (497, 1871) | 571 (511, 638) | 0.325 | 404 (195, 838) | 577 (515, 646) | 0.195 |
| Anti-19F OPA GMT (Min, Max) | 484 (295, 794) | 278 (249, 309) | 0.243 | 185 (59, 580) | 281 (252, 313) | 0.187 |
| Anti-23F OPA GMT (Min, Max) | 20 (3, 136) | 1701 (1483, 1950) | <0.0001 | 229 (37, 1411) | 1801 (1582, 2050) | <0.0001 |
Rows in shaded grey: antibodies against the carried serotype. (Min, Max) = Minimum and maximum range.
*
Note: The number of observations for the non-carriers, based on sample availability, is indicated in Table 4.