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. Author manuscript; available in PMC: 2012 Sep 16.
Published in final edited form as: Vaccine. 2011 Jul 30;29(40):6903–6910. doi: 10.1016/j.vaccine.2011.07.046

Fig. 2. Characterization of human b12 iHVs.

Fig. 2

a. Schematic drawing of human intermediate b12 scFv library. b. AA sequence alignment of the isolated human intermediate b12 HVs (iHVs) with human germline (Hub12-gHV) and mature (Hub12-mHV) HVs. c–d. Binding (c) and neutralization activities (c & d) of human b12 iHVs when recombined with human mature D(J)-segments linked to mature VL (-m) or with human germline D(J)-segments linked to human germline VL (-g). Human mature and germline b12 scFvs were included for comparison.