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. Author manuscript; available in PMC: 2011 Sep 7.
Published in final edited form as: Thalamus Relat Syst. 2007 Jan 22;3(3):181–203. doi: 10.1017/S1472928807000209

Fig. 3. Pentobarbital abolishes SWDs and induces spindle-like oscillations.

Fig. 3

(A) Top: Surface EEG recordings (truncated) over the primary somatosensory cortex in a GAERS under neuroleptic analgesia, which received a subanaesthetic dose of pentobarbital. Bottom: Expanded EEG traces. Before pentobarbital injection and during the recovery period, the EEG displays recurrent high-voltage SWDs of variable duration. Note that pentobarbital suppresses SWDs and induces the occurrence of spindle-like episodes (*) in a GAERS (A) and in a non-epileptic control (NEC) rat (B). (B) In a NEC rat, SM oscillations occur spontaneously before and at least 20–30min after pentobarbital injection (recovery). (C) Expanded traces of a typical SM oscillation recorded in a NEC rat (C1) and a SM oscillation that gives rise to a SWD in a GAERS (C2). (D) Three types of spindle-like oscillations recorded in GAERS and NEC rats after barbiturate administration: (D1) contains only sinusoid-like waves; (D2) biphasic spikes; and (D3) mainly monophasic spikes. Adapted from (Pinault et al., 2006).