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. 2000 Aug 1;14(15):1886–1898.

Figure 4.

Figure 4

Increased apoptosis but normal cell proliferation in Hus1−/− embryos. (A–D,F–I) Sections of Hus1 embryos were stained by the TUNEL method. (A,F) 7.5 dpc, (B,G) 8.0 dpc, (C,H) higher magnification view of boxed region in B and G, (D,I) 8.5 dpc. Arrows in A, C, F, and H indicate some of the TUNEL-positive apoptotic cells, which are darkly-stained in contrast to the methyl green counterstain. (E,J) Sections of BrdU-labeled Hus1 embryos at 7.5 dpc were stained with an anti-BrdU antibody. BrdU-positive cells are darkly-stained in contrast to the hematoxylin (blue) counterstain. Size bars: (A,D,F,I) 125 μm; (B,G) 250 μm; (C,E,H,J) 62.5 μm.