Table 4.

Distribution of the 3′ haplotype frequencies among different populations and the association between Brazilian populations and European (EUR) and Amerindian (AMR) ancestry.

		Haplotype frequency				Haplotype-specific test (BRZ)
HAP ID	3′ HAP	YRI	ASN	CEU	BRZ	AMR-ancestry		EUR-ancestry
						B	p	B	p
3′H01	ACGAGG	0.083	0.635	0.408	0.347	0.001	0.906	− 0.013	0.546
3′H02	GTTGTA	0.142	0.056	0.475	0.321	− 0.048	0.001*	0.053	0.020*
3′H03	GCTATA	0.125	0.219	0.100	0.101	0.041	0.018*	− 0.060	0.078
3′H04	GCTATG	−	0.022	−	0.035	0.045	0.099	− 0.105	0.041*
3′H05	ACGAGA	−	−	−	0.028	− 0.054	0.518	0.113	0.241
3′H06	GTGGTA	−	−	−	0.027	0.043	0.187	− 0.040	0.553
3′H07	ACTATA	0.117	0.011	−	0.023	0.029	0.487	0.023	0.845
3′H08	GCGATA	0.058	−	−	0.022	0.057	0.093	− 0.030	0.737
3′H09	ACGATG	−	−	−	0.020	− 0.045	0.378	0.088	0.262
3′H10	GTTGTG	−	−	−	0.018	0.034	0.452	− 0.003	0.979
3′H11	ACTATG	−	−	−	0.016	0.049	0.209	− 0.119	0.156
3′H12	GTTATA	0.017	0.011	−	0.016	0.003	0.944	− 0.090	0.181
3′H13	ATTGTA	−	−	−	0.013	− 0.134	0.161	0.280	0.082
3′H14	ACTGTA	0.092	−	−	0.012	− 0.122	0.164	0.199	0.188
3′H15	GCGAGG	0.167	0.017	−	−	−	−	−	−
3′H16	GTTAGG	0.108	−	−	−	−	−	−	−
3′H17	ACGATA	0.050	−	−	−	−	−	−	−
3′H18	ATTATA	0.017	0.011	−	−	−	−	−	−
3′H19	GCTGTA	−	0.011	−	−	−	−	−	−

HAP ID = Haplotype identity; 3′ HAP = Haplotypes in the 5′ gene region consisting of rs2248098, BsmI, ApaI, TaqI, rs9729 and rs7968585 SNPs. HapMap populations: ASN = Asian derived ancestry, CEU = European derived ancestry, YRI = African derived ancestry; BRZ = total Brazilian population. AMR = Amerindian genetic ancestry; EUR = European genetic ancestry. B = raw regression coefficient.

^*(p < 0.05) indicates a significant correlation.