Table 2.
Inactivation of ptc-1 activity by RNAi
| dsRNA injected
|
|
Phenotype of progeny
|
|||
|---|---|---|---|---|---|
| dead eggs
|
larval arrest
|
sterile adults
|
fertile adultsa
|
||
| ptc-1 (3.6 mg/ml) | average | 30% (13.7) | 2% (1.0) | 37% (17.1) | 31% (14.4) |
| Po = 7 | totalb | 96 | 7 | 120 | 101 |
| range | 6–27 | 0–4 | 6–28 | 13–18 | |
a
Wild-type adults were produced at the beginning of the brood and probably represent animals that were fertilized prior to the effects of dsRNA injection.
b
Total brood counts are low because RNAi disrupted the fertility of injected parents.