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. 2011 Aug;4(8):31–49.

TABLE 7.

Summary of studies investigating over-the-counter moisturizers in patients with erythematotelangiectatic rosacea and papulopustular rosacea

STUDY ROSACEA PATIENT SUBTYPE IN STUDY SELECTION PATIENT # (N) STUDY DESIGN EXPERIMENTAL GROUP REGIMEN CONTROL GROUP REGIMEN WASHOUT PERIOD STUDY PERIOD LENGTH
Draelos et al77 PPR N=66 Single site, investigator blinded, randomized, inter-individual comparison study PHA cleanser and moisturizer plus AzA 15% gel BID (Group 2) Self-selected cleanser and moisturizer plus AzA 15% gel BID (Group 1) two weeks with no topical products or systemic therapeutics 12 weeks
Laquieze et al79 ETR N=20 Randomized, intra-individual comparison study Nonalkaline moisturizer cream plus metronidazole 0.75% gel BID Metronidazole 0.75% gel BID two weeks using any moisturizer plus metronida zole 0.75% gel BID 2 weeks
Del Rosso4 PPR N=102 Multicenter, open label, intra- individual compariosn study Nonalkaline or ceramide-based cleanser and ccream plus AzA 15% gel BID (51) AzA 15% gel BID (51) None 1 week
STUDY SUBJECTIVE CLINICAL IMPROVEMENTS IN THE EXPERIMENTAL GROUP OBJECTIVE CLINICAL IMPROVEMENTS IN THE EXPERIMENTAL GROUP OBJECTIVE MEASUREMENT IMPROVEMENTS IN THE EXPERIMENTAL GROUP
Draelos et al77 None*

  1. Objective investigator improvement in Group 2 in skin sensitivity, dryness, texture, smoothness, and over skin condition (p<0.05)

  2. No differnce seen in treatement of PPR papules and pustules

  3. Draelos notes an improvement in Group 2 background erythema (n.s.)

 None**
Laquieze et al79

  1. Subjective improvement in dryness (p<0.05)

  2. Subjective improvement in roughness, desquamation, and discomfort (n.s.)

  1. Objective investigator improvement in dryness (p<0.05)

  2. Objective improvement in roughness, desquamation, and discomfort (n.s.)

  1. Electrical capacitance showed improvement in hydration (p<0.05)

  2. Lactic Acid Stinging Test showed improved skin senitivity (p<0.05)

  3. TEWL measurement decreased
Del Rosso4 Improvement in stinging, burning, itching, and tingling (cumulative symptom score) from baseline in the experimental group (p=0.008) None† None**
PPR

Papulopustular rosacea

ETR

Erythematotelangiectatic rosacea

n.s.

Nonsignificant conclusion stastistically (not statistically significant)

*

Subjective clinical improvements were not evaluated in this study

**

Objective measurements were not evaluated in this study

†

Objective clinical Improvements were not evaluated in this study