Table 2.

Genome-wide significant markers located in known regions^a

					Marginal analysis		Conditional analysis
SNP	Allelesb	Cytoband	Pos	Gene	OR (95% CI)	P-value	OR (95% CI)	P-value
rs7629490c	C/T	3p11	87324187	–	1.15 (1.10–1.19)	1.9 × 10−10	1.06 (1.04–1.09)	1.2 × 10−7
rs651164d	G/A	6q25	160501364	SLC22A1	0.85 (0.81–0.89)	1.4 × 10−13	0.87 (0.83–0.91)	2.2 × 10−10
rs13252298e	A/G	8q24	128164338	–	0.85 (0.81–0.89)	4.5 × 10−12	0.89 (0.85–0.95)	4.3 × 10−6
rs6999921e	G/A	8q24	128510110	–	0.81 (0.75–0.87)	7.4 × 10−9	0.90 (0.83–0.97)	7.0 × 10−3
rs1447293e	T/C	8q24	128541502	–	1.14 (1.09–1.18)	3.1 × 10−9	1.00 (0.95–1.04)	0.84
rs11228594f	A/G	11q13	68779663	–	0.87 (0.83–0.91)	1.2 × 10−9	0.90 (0.86–0.95)	2.4 × 10−5
rs7940107f,g	G/A	11q13	68784346	–	1.20 (1.12–1.28)	4.7 × 10−8	1.06 (1.02–1.11)	3.6 × 10−3
rs742134h	A/G	22q13	41848219	BIK	1.20 (1.15–1.33)	5.6 × 10−9	1.16 (1.01–1.23)	5.9 × 10−6

^aUnless otherwise specified, results are from combined Stage 1 and in silico replication studies, including both advanced and non-advanced cases.

^bReference allele/risk allele; the odds ratio is the change in odds per additional copy of the risk allele.

^cConditional analyses adjusted for rs2660753.

^dConditional analyses adjusted for rs9364554.

^eConditional analyses adjusted for rs7841060, rs16901979, rs620861, rs6983267, rs4242382.

^fConditional analyses adjusted for rs10896449.

^gResults from advanced-only analysis.

^hConditional analyses adjusted for rs5759167.