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. 2011 Sep 7;6(9):e23898. doi: 10.1371/journal.pone.0023898

Figure 3. The KCNQ activator, Zinc pyrithione enhances dKCNQ current.

Figure 3

Representative traces (A), I-V (B) and G-V (C) plots showing 10 µM zinc pyrithione causes strong activation of dKCNQ compared to control, as has previously been reported for mammalian KCNQ channels [11]. Addition of zinc pyrithione did not change (p>0.05) the slope factor of dKCNQ (slope factor with drug = 18.7±3.9 mV) compared to control (slope factor = 18.1±3.9 mV, n = 5). The activation by zinc pyrithione was reversible. n = 5.