Table 1. Estimates of the model parameters.
| Parameter designation and meaning | In vitro data(AML 193 cell line) | Clinical data(blast cells from AML patients) |
| Rp, CD33 production rate (molecules cell−1 hour−1) | 2047 | 279 (109.6)* |
| ke, Free CD33 internalization rate (hour−1) | 0.12 | 0.213 (65.7) |
| ki, GO-CD33 complex internalization rate (hour−1) | 0.4 | 0.66 (50) |
| kd, GO efflux rate (hour−1) | NM | 0.34 (64.7) |
| kb, GO-CD33 association rate (M−1 hour−1) | 1.1×1012 | NM |
| ku, GO-CD33 dissociation rate (hour−1) | 397.1 | NM |
| k, Non specific drug elimination rate (hour−1) | NA | 0.01919 |
| N0, Initial total number of blast cells | NA | 2.47×1012 |
| α, Blast elimination rate (hour−1) | NA | 0.104 |
| V, Volume of distribution of GO (L) | NA | 6.2 |
*results of fitting clinical data are reported as mean, and inter-patient% CV (coefficient of variation)
for those parameters for which estimation in individual patients was possible; NM – not measured;
NA - not applicable; GO – Gemtuzumab Ozogamicin.