Table 2. In vitro growth parameters for the strains of the first isogenic system based on E. coli CFT073 carrying pBR322 derivatives harboring qnrA3 or not.
| E. coli strains | Maximal growth rate in log(OD)/h. | Doubling time in min | Maximal OD | |||
| mean | p a | mean | p a | mean | p a | |
| CFT073(pBRΔtetA) | 0.96 (+/−0.02) | - | 18.9 (+/−0.3) | - | 1.07 (+/−0.02) | - |
| CFT073(pBR322) | 0.94 (+/−0.02) | 0.21 | 19.2(+/−0.3) | 0.21 | 1.05 (+/−0.06) | 0.6 |
| CFT073(pBRAM1) | 0.94 (+/−0.01) | 0.17 | 19.2 (+/−0.3) | 0.17 | 1.11 (+/−0.02) | 0.005 |
| CFT073(pBRAM2) | 0.94 (+/−0.02) | 0.13 | 19.2 (+/−0.5) | 0.13 | 1.10 (+/−0.02) | 0.01 |
Data obtained from automatic OD measurements (n = 15) in Trypticase Soy Broth and expressed as mean and confidence interval 95%.
a
The comparison was performed with a Wilcoxon test between each strains and the corresponding control qnr-negative strain CFT073(pBRΔtetA). p<0.05 was considered significant.